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As an active form is secreted, its activity must be tightly regulated to avoid detrimental effects.
MMP-14 cleaves MMP-11 catalytic domain at the PGG(P1)-I(P1')LA and V/IQH(P1)-L(P1')YG scissile bonds, two new cleavage sites.
Interestingly, a functional test showed a dramatical reduction in MMP-11 enzymatic activity when incubated with active MMP-14, whereas inactive point-mutated MMP-14 had no effect.
This function is conserved between human and mouse.
Thus, in addition to the canonical reversible TIMP-dependent inhibitory system, irreversible MMP proteolytic inactivation might occur by cleavage of the catalytic domain in a MMP-dependent manner.
Since MMP-14 is produced by HT-1080 cancer cells, whereas MMP-11 is secreted by HFL1 stromal cells, our findings support the emerging importance of tumor-stroma interaction/cross-talk.
Moreover, they highlight a Janus-faced MMP-14 function in the MMP cascade, favoring activation of several pro-MMPs, but limiting MMP-11 activity. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Finally, both MMPs are active at the cell periphery. MMP-11 is a key factor in physiopathological tissue remodeling.
The Transgender Erotica Awards was a two-day event on Sunday, February 15th and 16th, 2015.
The awards ceremony was held at the Avalon in Los Angeles, California, followed by the official After Party at the Bardot.
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MMP-11 is a key factor in physiopathological tissue remodeling.